Science and Technology Daily Beijing November 4 (Reporter Zhang Mengran) American researchers found a key molecule in certain types of breast cancer, which prevent immunocytes from entering tumors to kill internal cancer cells.
3 days was published in the British "Nature" magazine or to find new therapies to find some invasive breast cancer. Dr. Li Rong, the main author of the paper It can prevent immunocytes from entering tumors.
It is learned that DDR1 molecules form a protective boundary around tumors, enabling researchers to prove that when DDR1 is disabled, immune cells can penetrate into tumors and kill internal tumor cells. Li Rong team studied three-negative breast cancer, which is an invasive cancer that accounts for about 15% of all breast cancer cases.
According to the American Disease Control and Prevention Center, this type of cancer lacks a receptor commonly used in cancer treatment, so it is difficult to target tumor cells.
The goal of immunotherapy is to activate them when immunocytes reach the tumor center, but DDR1 molecules are a physical barrier for anti-tumor immune cells.
Li Rong said that this potential mechanism provides a new method to help people find new drugs for this difficult cancer. The researchers evaluated the impact of DDR1 in multiple clinical prior models. They determined that removing DDR1 not only prevents tumor growth, but also protects the body from future tumors. Combined with these new discoveries, researchers have developed a therapeutic DDR1 targeted antibody that breaks the defense line to help immune cells kill tumors through barriers. The researchers said that the important role of DDR1 in anti-cancer is a major progress and may alter the treatment pathway.
With more comprehensive understanding of DDR1, researchers also want to identify other molecules similar to DDR1 and use the same method to fight against other cancers. The total editorial circle of breast cancer is a type of cancer that leads to the most female death, while three-negative breast cancer is the most difficult subtype, because compared to other breast cancer, it has a smaller age, more easily transferred – – It is tricky in the medical community, which is also higher after postoperative recurrence probability.
But now, scientists have found the key to triple-negative breast cancer so difficult to deal with. It is said that this is a "significant progress", because with this discovery, the medical community will change the idea of ??anti-triple-negative breast cancer, so that people see the dawn of this "devil".